Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the
respective nucleosides. Within the past decade, ectonucleotidases belonging to several …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

A cDNA was isolated from a human monocyte library that encodes the P2X 7 receptor; the
predicted protein is 80% identical to the rat receptor. Whole cell recordings were made from …

Functional and molecular analysis of glial voltage-and ligand-gated ion channels underwent
tremendous boost over the last 15 years. The traditional image of the glial cell as a passive …

P2X receptors are cation channels gated by extracellular ATP. The seven known P2X
isoforms possess no sequence homology with other proteins. Here we studied the …

cytokines and other products of the immune cells can modulate the action, differentiation,
and survival of neuronal cells, while the neurotransmitter and neuropeptide release play a …

P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The
seven subunits cloned (P2X1–7) can assemble to form homomeric and heteromeric …

The P2X7 receptor is a uniquely bifunctional molecule through which ATP can open a small
cationic channel typical of ionotropic receptors and also induce a large pore permeable to …