The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …

Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …

While mRNA SARS-CoV-2 vaccination elicits strong humoral responses in the general
population, humoral responses in people living with HIV (PLWH) remain to be clarified …

Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-
CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral …

Summary HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4+
T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env …

The continued evolution of severe acute respiratory syndrome 2 (SARS-CoV-2) requires
persistent monitoring of its subvariants. Omicron subvariants are responsible for the vast …

The use of computer simulation methods has become an indispensable component in
identifying drugs against the SARS-CoV-2 coronavirus. There is a huge body of literature on …

ABSTRACT Coronavirus disease 2019 (COVID-19) is a major global health emergency, with
more than six million deaths worldwide. It is becoming increasingly challenging to treat …

Direct acting antivirals (DAAs) represent critical tools for combating SARS-CoV-2 variants of
concern (VOCs) that evolve to escape spike-based immunity and future coronaviruses with …

SARS-CoV-2 continues to infect millions of people worldwide. The subvariants arising from
the variant-of-concern (VOC) Omicron include BA. 1, BA. 1.1, BA. 2, BA. 2.12. 1, BA. 4, and …