Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …

VEGF is unique among angiogenic growth factors because it disrupts endothelial barrier
function. Therefore, we considered whether this property of VEGF might contribute to tumor …

Prostate cancer is a complex disease in which metastasis to the bone is the main cause of
death. Initial stages of metastasis are generally similar to those for most solid tumors; …

The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-
related gene (Arg). Activated forms of the Abl kinases (BCR-Abl, Tel-Abl, and Tel-Arg) …

Src tyrosine kinase expression and activity are elevated during colon cancer progression.
How this contributes to the malignant phenotype is not fully understood. We show that in …

Abstract The Src family kinases (SFKs) are the largest family of nonreceptor protein tyrosine
kinases and are responsible for signal transduction during many cellular activities, including …

Acute inflammatory responses are one of the major underlying mechanisms for tissue
damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung …

The aberrant behavior of cancer reflects upregulation of certain oncogenic signaling
pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and …

BACKGROUND: To determine the potential efficacy of targeting both the tumor and bone
microenvironment in patients with castration‐resistant prostate cancer (PC), the authors …