PANoptosis: Mechanisms, biology, and role in disease
X Sun, Y Yang, X Meng, J Li, X Liu… - Immunological …, 2024 - Wiley Online Library
Cell death can be executed through distinct subroutines. PANoptosis is a unique
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
inflammatory cell death modality involving the interactions between pyroptosis, apoptosis …
Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis
The delivery of pathogens to lysosomes for degradation provides an important defense
against infection. Degradation is enhanced when LC3 is conjugated to endosomes and …
against infection. Degradation is enhanced when LC3 is conjugated to endosomes and …
A bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy
Antibacterial autophagy (xenophagy) is an important host defense, but how it is initiated is
unclear. Here, we performed a bacterial transposon screen and identified a T3SS effector …
unclear. Here, we performed a bacterial transposon screen and identified a T3SS effector …
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy
Y Xu, S Cheng, H Zeng, P Zhou, Y Ma, L Li… - Nature structural & …, 2022 - nature.com
Selective autophagy helps eukaryotes to cope with endogenous dangers or foreign
invaders; its initiation often involves membrane damage. By studying a Salmonella effector …
invaders; its initiation often involves membrane damage. By studying a Salmonella effector …
Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica
TSR Powers, AL Haeberle, AV Predeus… - PLoS …, 2021 - journals.plos.org
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that
causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium …
causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium …
[HTML][HTML] Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading
microorganisms through autophagic machinery. The intracellular bacterial pathogen …
microorganisms through autophagic machinery. The intracellular bacterial pathogen …
Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection
H Yuan, L Zhou, Y Chen, J You, H Hu, Y Li… - Gut …, 2023 - Taylor & Francis
SopF, a newly discovered effector secreted by Salmonella pathogenicity island-1 type III
secretion system (T3SS1), was reported to target phosphoinositide on host cell membrane …
secretion system (T3SS1), was reported to target phosphoinositide on host cell membrane …
SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole
N Lau, AL Haeberle, BJ O'Keeffe, EA Latomanski… - PLoS …, 2019 - journals.plos.org
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium),
utilizes two type III secretion systems (T3SSs) to invade host cells, survive and replicate …
utilizes two type III secretion systems (T3SSs) to invade host cells, survive and replicate …
Speaking the host language: how Salmonella effector proteins manipulate the host
TD Pillay, SU Hettiarachchi, J Gan… - …, 2023 - microbiologyresearch.org
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …
Mitigation of T3SS-mediated virulence in waterborne pathogenic bacteria by multi-electrode cylindrical-DBD plasma-generated nitric oxide water
Abstract S. enterica, S. flexneri, and V. parahaemolyticus bacteria are globally recognized to
cause severe diarrheal diseases, consisting of Type III Secretion System (T3SS) effectors …
cause severe diarrheal diseases, consisting of Type III Secretion System (T3SS) effectors …