Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

The skeletal system contains a series of sophisticated cellular lineages arising from the
mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) that determine the …

The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here,
we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated …

Background Late in the nineteenth century, it was theorized that a circulating product
produced by the parathyroid glands could negatively impact skeletal homeostasis. A century …

BM adipocytes (BMAd) are a unique cell population derived from BM mesenchymal
progenitors and marrow adipogenic lineage precursors. Although they have long been …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Osteoporosis is a systemic metabolic bone disease characterized by the descending bone
mass and destruction of bone microstructure, which tends to result in the increased bone …