Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Clearance of apoptotic cells by macrophages prevents excessive inflammation and supports
immune tolerance. Here, we examined the effect of blocking apoptotic cell clearance on anti …

The respective antitumoral and protumoral roles of M1 and M2 tumor-associated
macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

The tumor immune microenvironment is a determinant of response to cancer
immunotherapy and, in many cases, is prognostic for patient survival independently of the …

Macrophages are one of the most abundant non‐malignant cells in the tumor
microenvironment, playing critical roles in mediating tumor immunity. As important innate …

Immunotherapy is reshaping cancer treatment paradigms; however, response rates to
immune therapies are low and depend on the host's pre-existing antitumor immunity. The …

As one of the four major means of cancer treatment including surgery, radiotherapy (RT),
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …

Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that
radiotherapy synergizes with immunotherapy, promoting radiation-induced antitumor …