Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement

J Herrmann, D Lenihan, S Armenian… - European heart …, 2022 - academic.oup.com
Abstract The discipline of Cardio-Oncology has seen tremendous growth over the past
decade. It is devoted to the cardiovascular (CV) care of the cancer patient, especially to the …

Clinical strategy for the diagnosis and treatment of immune checkpoint inhibitor–associated myocarditis: a narrative review

LH Lehmann, J Cautela, N Palaskas, AH Baik… - JAMA …, 2021 - jamanetwork.com
Importance In the last decade, immune checkpoint inhibitors (ICIs) have been approved for
the treatment of many cancer types. Immune checkpoint inhibitor–associated myocarditis …

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic …

AR Lyon, T Lopez-Fernandez, LS Couch… - European Heart …, 2022 - academic.oup.com
ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque

ZD Drobni, RM Alvi, J Taron, A Zafar, SP Murphy… - Circulation, 2020 - Am Heart Assoc
Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers.
Consistent basic data suggest that these same checkpoints are critical negative regulators of …

[HTML][HTML] Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors

AC Guidon, LB Burton, BK Chwalisz… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Expanding the US Food and Drug Administration–approved indications for immune
checkpoint inhibitors in patients with cancer has resulted in therapeutic success and …

Myocardial T1 and T2 mapping by magnetic resonance in patients with immune checkpoint inhibitor–associated myocarditis

P Thavendiranathan, L Zhang, A Zafar… - Journal of the American …, 2021 - jacc.org
Background Myocarditis is a potentially fatal complication of immune checkpoint inhibitor
(ICI) therapy. Data on the utility of cardiovascular magnetic resonance (CMR) T1 and T2 …

Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆

J Haanen, M Obeid, L Spain, F Carbonnel… - Annals of …, 2022 - annalsofoncology.org
Adverse events (AEs) related to the use of immune checkpoint inhibitor (ICI) therapy are
defined as immune-related (IR) AEs (irAEs). irAEs are graded according to the Common …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events

MV Maus, S Alexander, MR Bishop… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Immune effector cell (IEC) therapies offer durable and sustained remissions in significant
numbers of patients with hematological cancers. While these unique immunotherapies have …

Major adverse cardiovascular events and the timing and dose of corticosteroids in immune checkpoint Inhibitor–Associated myocarditis

L Zhang, DA Zlotoff, M Awadalla, SS Mahmood… - Circulation, 2020 - Am Heart Assoc
MACE independent of age, sex, lowest left ventricular ejection fraction, and time of initiation
(hazard ratio, 0.27 [95% CI, 0.09–0.84]; P= 0.024). Patients receiving corticosteroids within …

The Evolving Immunotherapy Landscape and the Epidemiology, Diagnosis, and Management of Cardiotoxicity: JACC: CardioOncology Primer

L Zhang, KL Reynolds, AR Lyon, N Palaskas… - Cardio Oncology, 2021 - jacc.org
Immune checkpoint inhibitors (ICIs) are newer therapies being applied to an increasing
number of patients with cancer. Data suggest that up to 36% of cancer patients may be …