BACKGROUND Ribosomopathies are a heterogeneous group of human disorders that are
in some cases known, and in other cases suspected, to result from ribosome dysfunction …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

Stem-cell-derived tissues could transform disease research and therapy, yet most methods
generate functionally immature products. We investigate how human pluripotent stem cells …

Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene
programs controlling cell differentiation and function. Central to their functions is an ability to …

Dynamic cellular processes such as differentiation are driven by changes in the abundances
of transcription factors (TFs). However, despite years of studies, our knowledge about the …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …

Abstract The 5′ untranslated region (5′ UTR) is critical in determining post-transcriptional
control, which is partly mediated by short upstream open reading frames (uORFs) present in …

Enhancer-derived RNAs are thought to act locally by contributing to their parent enhancer
function. Whether large domains of clustered enhancers (super-enhancers) also produce cis …

Biomolecular condensates concentrate molecules to facilitate basic biochemical processes,
including transcription and DNA replication. While liquid-like condensates have been …