The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …

Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

Lymphoedema is the swelling of one or several parts of the body owing to lymph
accumulation in the extracellular space. It is often chronic, worsens if untreated, predisposes …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Simple Summary The extracellular matrix (ECM) is the acellular part of a tissue, a meshwork
of extracellular material produced and secreted by cells into the surrounding medium. The …

The cell microenvironment choreographs the behaviors of cells through multiple well-
controlled signals. For basic biological study and cell-based therapies, it is essential to …