Immunological studies of single proteins in a single cell type have been complemented in
recent years by larger studies, enabled by emerging high-throughput technologies. This …

Since the 1980s, growing evidence suggested that the cellular localization of proteins
determined their activity and biological functions. In a classical view, a protein is …

Derived from mesoderm precursors, hemangioblasts are bipotential common progenitors of
hematopoietic cells and endothelial cells. The regulatory events controlling hematopoietic …

In contrast to the somatic cells, embryonic stem cells (ESCs) are characterized by its
immortalization ability, pluripotency, and oncogenicity. Revealing the underlying mechanism …

Glioblastom (GBM) je nejagresivnější a nejčastější maligní primární mozkový nádor, který se
vyznačuje změnami extracelulární matrix (ECM). K těmto změnám může přispívat …

Advances in single-cell sequencing technologies present an opportunity to study the cellular
and molecular basis of complex tissue physiology at global scale with unprecedented …

Breast cancer is an extremely heterogeneous disease comprising at least ten different
subtypes, each exhibiting different characteristics in progression, prognosis and response to …

Les érythrocytes (globules rouges, GR) transportent le dioxygène (via l'hémoglobine) des
poumons aux tissus de l'organisme. Leur production est assurée par des cellules souches …

Quiescent cancer cells with tumor propagating potential are widely believed to contribute to
therapy resistance and clinical recurrence. Still, their systematic identification, molecular …

The transcription factors SMAD2 and SMAD3 are the effectors of classical transforming
growth factor beta (TGFβ) signalling. This signalling cascade is involved in many cellular …