Regulation of thyroid-disrupting chemicals to protect the developing brain
ME Gilbert, KL O'Shaughnessy, M Axelstad - Endocrinology, 2020 - academic.oup.com
Synthetic chemicals with endocrine disrupting properties are pervasive in the environment
and are present in the bodies of humans and wildlife. As thyroid hormones (THs) control …
and are present in the bodies of humans and wildlife. As thyroid hormones (THs) control …
Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption
D Knapen, E Stinckens, JE Cavallin… - Environmental …, 2020 - ACS Publications
A growing number of environmental pollutants are known to adversely affect the thyroid
hormone system, and major gaps have been identified in the tools available for the …
hormone system, and major gaps have been identified in the tools available for the …
Thyroid disrupting chemicals and developmental neurotoxicity–New tools and approaches to evaluate hormone action
KL O'Shaughnessy, ME Gilbert - Molecular and cellular endocrinology, 2020 - Elsevier
It is well documented that thyroid hormone (TH) action is critical for normal brain
development and is mediated by both nuclear and extranuclear pathways. Given this …
development and is mediated by both nuclear and extranuclear pathways. Given this …
Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals—the athena project
A Kortenkamp, M Axelstad, AH Baig… - International Journal of …, 2020 - mdpi.com
The test methods that currently exist for the identification of thyroid hormone system-
disrupting chemicals are woefully inadequate. There are currently no internationally …
disrupting chemicals are woefully inadequate. There are currently no internationally …
Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?
AA Li, SL Makris, MS Marty, V Strauss… - Regulatory Toxicology …, 2019 - Elsevier
Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular,
reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent …
reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent …