Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade
G Crișan, NS Moldovean-Cioroianu… - International journal of …, 2022 - mdpi.com
Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …
imaging of several metabolic processes, blood flow measurements, regional chemical …
Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics
P Bannas, J Hambach, F Koch-Nolte - Frontiers in immunology, 2017 - frontiersin.org
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
Nanobodies as therapeutics: big opportunities for small antibodies
S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics
M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …
their applications are still hampered in therapeutic development due to limitations, such as …
Nanobodies as versatile tools to understand, diagnose, visualize and treat cancer
I Van Audenhove, J Gettemans - EBioMedicine, 2016 - thelancet.com
Since their discovery, nanobodies have been used extensively in the fields of research,
diagnostics and therapy. These antigen binding fragments, originating from Camelid heavy …
diagnostics and therapy. These antigen binding fragments, originating from Camelid heavy …
Targeted cancer therapy through antibody fragments-decorated nanomedicines
A Alibakhshi, FA Kahaki, S Ahangarzadeh… - Journal of Controlled …, 2017 - Elsevier
Active targeting in cancer nanomedicine, for improved delivery of agents and diagnose, has
been reviewed as a successful way for facilitating active uptake of theranostic agents by the …
been reviewed as a successful way for facilitating active uptake of theranostic agents by the …
Nanobodies in cancer
ER Verhaar, AW Woodham, HL Ploegh - Seminars in immunology, 2021 - Elsevier
For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …
a first line of therapy for certain cancers. A unique class of antibody fragments called …
Targeted radionuclide therapy of prostate cancer—from basic research to clinical perspectives
M Czerwińska, A Bilewicz, M Kruszewski… - Molecules, 2020 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …
leading cause of cancer-related deaths in Western civilization. Although localized prostate …
[HTML][HTML] Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody
M D'Huyvetter, C Vincke, C Xavier, A Aerts… - Theranostics, 2014 - ncbi.nlm.nih.gov
RIT has become an attractive strategy in cancer treatment, but still faces important
drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting …
drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting …
Same-day imaging using small proteins: clinical experience and translational prospects in oncology
Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …