Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade

G Crișan, NS Moldovean-Cioroianu… - International journal of …, 2022 - mdpi.com
Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics

P Bannas, J Hambach, F Koch-Nolte - Frontiers in immunology, 2017 - frontiersin.org
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …

Nanobodies as therapeutics: big opportunities for small antibodies

S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics

M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …

Nanobodies as versatile tools to understand, diagnose, visualize and treat cancer

I Van Audenhove, J Gettemans - EBioMedicine, 2016 - thelancet.com
Since their discovery, nanobodies have been used extensively in the fields of research,
diagnostics and therapy. These antigen binding fragments, originating from Camelid heavy …

Targeted cancer therapy through antibody fragments-decorated nanomedicines

A Alibakhshi, FA Kahaki, S Ahangarzadeh… - Journal of Controlled …, 2017 - Elsevier
Active targeting in cancer nanomedicine, for improved delivery of agents and diagnose, has
been reviewed as a successful way for facilitating active uptake of theranostic agents by the …

Nanobodies in cancer

ER Verhaar, AW Woodham, HL Ploegh - Seminars in immunology, 2021 - Elsevier
For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …

Targeted radionuclide therapy of prostate cancer—from basic research to clinical perspectives

M Czerwińska, A Bilewicz, M Kruszewski… - Molecules, 2020 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …

[HTML][HTML] Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody

M D'Huyvetter, C Vincke, C Xavier, A Aerts… - Theranostics, 2014 - ncbi.nlm.nih.gov
RIT has become an attractive strategy in cancer treatment, but still faces important
drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting …

Same-day imaging using small proteins: clinical experience and translational prospects in oncology

A Krasniqi, M D'Huyvetter, N Devoogdt… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …