The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …

Radiation triage and biological dosimetry are two initial steps in the medical management of
exposed individuals following radiological accidents. Well established biodosimetry …

The spatial distribution of radiation-induced DNA breaks within the cell nucleus depends on
radiation quality in terms of energy deposition pattern. It is generally assumed that the higher …

Phosphorylation of the histone protein H2AX to form γ-H2AX foci directly represents DNA
double-strand break formation. Traditional γ-H2AX detection involves counting individual …

The visualisation of DNA damage response proteins enables the indirect measurement of
DNA damage. Soon after the occurrence of a DNA double-strand break (DSB), the formation …

In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a
useful tool to estimate radiation doses received by individuals. The rapid processing time of …

In the event of a large-scale radiological emergency, the triage of individuals according to
their degree of exposure forms an important initial step of the accident management …

Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising
radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB …

Purpose To apply our previously published residual ex vivo γH2AX foci method to patient-
derived tumour specimens covering a spectrum of tumour-types with known differences in …

The objective of this work was to examine differences in DNA double‐strand break induction
in peripheral blood lymphocytes after in vitro X‐ray irradiation between iodinated contrast …