Background The objective of this article is to summarize the published literature concerning
the pharmacokinetics and pharmacodynamics of oral anticoagulant drugs that are currently …

rin. 25, 26 Inhibition of S-warfarin metabolism is more important clinically because this
isomer is 5 times more potent than the R-isomer as a vitamin K antagonist. 25, 26 …

This article concerning the pharmacokinetics and pharmacodynamics of vitamin K
antagonists (VKAs) is part of the American College of Chest Physicians Evidence-Based …

Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-
founded fear of bleeding. Drug and food interactions are frequently cited as causes of …

Abbreviations: AFASAK Atrial Fibrillation, Aspirin, Anticoagulation; AMI acute myocardial
infarction; AF atrial fibrillation; CARS Coumadin Aspirin Reinfarction Study; CI confidence …

This article concerning the pharmacokinetics and pharmacodynamics of vitamin K
antagonists (VKAs) is part of the Seventh American College of Chest Physicians Conference …

This widely used text uses a case-based approach to help students master the fundamentals
of drug therapeutics. Students will learn the basics of common diseases and disorders and …

This article about hemorrhagic complications of anticoagulant and thrombolytic treatment is
part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians …

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United
States. It is a complex disease whose etiology bridges biomechanics and biochemistry …

Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …