Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic
nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to …

Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …

Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …

Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are
currently considered the most significant and prevalent metabolic changes observed in …

O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational
modification consisting in the addition of a sugar moiety to serine/threonine residues of …

Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential
and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose …

Prostate cancer is one of the most commonly diagnosed cancers in men and is a major
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …