[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps

W Zou, R Zhang, E Schüler, PA Taylor… - International Journal of …, 2023 - Elsevier
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …

Present state and issues in IORT physics

FW Hensley - Radiation Oncology, 2017 - Springer
Literature was reviewed to assess the physical aspects governing the present and emerging
technologies used in intraoperative radiation therapy (IORT). Three major technologies were …

Commissioning of an ultra‐high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols

R Moeckli, P Gonçalves Jorge, V Grilj… - Medical …, 2021 - Wiley Online Library
Purpose To present the acceptance and the commissioning, to define the reference dose,
and to prepare the reference data for a quality assessment (QA) program of an ultra‐high …

Dual beam‐current transformer design for monitoring and reporting of electron ultra‐high dose rate (FLASH) beam parameters

K Liu, A Palmiero, N Chopra… - Journal of applied …, 2023 - Wiley Online Library
Purpose To investigate the usefulness and effectiveness of a dual beam‐current transformer
(BCTs) design to monitor and record the beam dosimetry output and energy of pulsed …

Recommendations for clinical electron beam dosimetry: supplement to the recommendations of Task Group 25

BJ Gerbi, JA Antolak, FC Deibel, DS Followill… - Medical …, 2009 - Wiley Online Library
The goal of Task Group 25 (TG‐25) of the Radiation Therapy Committee of the American
Association of Physicists in Medicine (AAPM) was to provide a methodology and set of …

Intraoperative radiotherapy in brain malignancies: indications and outcomes in primary and metastatic brain tumors

CP Cifarelli, GM Jacobson - Frontiers in Oncology, 2021 - frontiersin.org
Despite the continued controversy over defining an optimal delivery mechanism, the critical
role of adjuvant radiation in the management of surgically resected primary and metastatic …

Intraoperative radiotherapy with INTRABEAM: technical and dosimetric considerations

A Sethi, B Emami, W Small Jr, TO Thomas - Frontiers in oncology, 2018 - frontiersin.org
Purpose We evaluate dose characteristics and clinical applications of treatment accessories
used in intraoperative radiotherapy (IORT) and make site-specific recommendations for their …

[HTML][HTML] Technological basis for clinical trials in FLASH radiation therapy: A review

Y Wu, HJ No, DY Breitkreutz… - Appl Rad …, 2021 - appliedradiationoncology.com
FLASH radiation therapy (RT) has shown potential to increase the therapeutic index for
cancer treatment. In vivo animal studies have shown a differential response between normal …

Application of failure mode and effects analysis to intraoperative radiation therapy using mobile electron linear accelerators

M Ciocca, MC Cantone, I Veronese, F Cattani… - International Journal of …, 2012 - Elsevier
PURPOSE: Failure mode and effects analysis (FMEA) represents a prospective approach for
risk assessment. A multidisciplinary working group of the Italian Association for Medical …

GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications

G Franciosini, G Battistoni, A Cerqua… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. The Monte Carlo simulation software is a valuable tool in radiation therapy, in
particular to achieve the needed accuracy in the dose evaluation for the treatment plans …