The microbiota-gut-brain axis in sleep disorders

Z Wang, Z Wang, T Lu, W Chen, W Yan, K Yuan… - Sleep medicine …, 2022 - Elsevier
Sleep is a complex physiological process and is a critical determinant of physical and
mental health. In the past decades, significant progress has been made in understanding …

Update on persistent excessive daytime sleepiness in OSA

S Javaheri, S Javaheri - Chest, 2020 - Elsevier
OSA is a highly prevalent sleep disorder, and subjective excessive daytime sleepiness
(EDS) is the cardinal symptom for which many individuals seek medical advice. Positive …

Obstructive sleep apnea is related to alterations in fecal microbiome and impaired intestinal barrier function

Q Li, T Xu, C Shao, W Gao, M Wang, Y Dong, X Wang… - Scientific reports, 2023 - nature.com
Abstract Obstructive Sleep Apnea (OSA) is related to repeated upper airway collapse,
intermittent hypoxia, and intestinal barrier dysfunction. The resulting damage to the intestinal …

[HTML][HTML] Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review

X Zhang, S Wang, H Xu, H Yi, J Guan… - European Respiratory …, 2021 - Eur Respiratory Soc
Introduction Obstructive sleep apnoea (OSA) is a common sleep disorder with a high social
and economic burden. Thus, early prediction and diagnosis of OSA are important. Changes …

Obstructive sleep apnea and systemic hypertension: gut dysbiosis as the mediator?

S Mashaqi, D Gozal - Journal of Clinical Sleep Medicine, 2019 - jcsm.aasm.org
Introduction: Obstructive sleep apnea (OSA) and systemic hypertension (SH) are common
and interrelated diseases. It is estimated that approximately 75% of treatment-resistant …

Gut microbiota mediate vascular dysfunction in a murine model of sleep apnoea: effect of probiotics

M Badran, A Khalyfa, AC Ericsson… - European …, 2023 - Eur Respiratory Soc
Background Obstructive sleep apnoea (OSA) is a chronic prevalent condition characterised
by intermittent hypoxia (IH), and is associated with endothelial dysfunction and coronary …

Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome

Y Ju, Z Zhang, M Liu, S Lin, Q Sun, Z Song, W Liang… - Genome Biology, 2024 - Springer
Background Respiratory diseases impose an immense health burden worldwide.
Epidemiological studies have revealed extensive disparities in the incidence and severity of …

Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis

I Ayappa, R Laumbach, K Black… - Journal of Clinical …, 2024 - jcsm.aasm.org
Study Objectives: We have previously estimated that the prevalence of obstructive sleep
apnea (OSA) among World Trade Center rescue and recovery workers is 75% and identified …

Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model

TJ Sanada, K Hosomi, H Shoji, J Park… - Pulmonary …, 2020 - journals.sagepub.com
The pathogenesis of pulmonary arterial hypertension is closely associated with
dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition …

The microbiome in obstructive sleep apnea

Y Cai, HM Juszczak, EK Cope, AN Goldberg - Sleep, 2021 - academic.oup.com
Recent evidence has highlighted important associations between obstructive sleep apnea
and the microbiome. Although the intricacies of the pathophysiologic mechanisms are not …