Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction,
leading to muscle weakness and fatigue. MG is caused by antibodies against the …

Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …

Plasma cells are unique immune effectors, capable of producing large amounts of high-
affinity antibodies that protect against pathogenic infections. Although most plasma cells …

Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are
reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of …

The continued evolution of SARS-CoV-2 underscores the need to understand qualitative
aspects of the humoral immune response elicited by spike immunization. Here, we combine …

Long-lived plasma cells (PCs) secrete antibodies that can provide sustained immunity
against infection. High-affinity cells are proposed to preferentially select into this …

Haematologic malignancies commonly arise from the bone marrow lesion, yet there are
currently no effective targeted therapies against tumour cells in this location. Here we …

Highlights•Specialized plasma cells (PCs) reside in multiple tissues throughout the body.•A
clonally related network of Immunoglobulin (Ig) A PCs occurs at mucosal sites.•Bone marrow …

The proper regulation of IgE production safeguards against allergic disease, highlighting the
importance of mechanisms that restrict IgE plasma cell (PC) survival. IgE PCs have …

Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently
releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different …