HDOCK update for modeling protein‐RNA/DNA complex structures

H Li, E Huang, Y Zhang, SY Huang, Y Xiao - Protein Science, 2022 - Wiley Online Library
Protein‐nucleic acid interactions are involved in various cellular processes. Therefore,
determining the structures of protein‐nucleic acid complexes can provide insights into the …

Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization

S Singh, S Machida, NK Tulsian, YK Choong… - Advanced …, 2023 - Wiley Online Library
HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts
with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor …

The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis

A Gijsbers, M Eymery, Y Gao, I Menart… - Journal of Biological …, 2023 - ASBMB
Pathogenic species from the Mycobacterium genus are responsible for a number of adverse
health conditions in humans and animals that threaten health security and the economy …

Heteromerization of dopamine D2 and oxytocin receptor in adult striatal astrocytes

S Amato, M Averna, D Guidolin, C Ceccoli… - International Journal of …, 2023 - mdpi.com
The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-
OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly …

Heterodimer of A2A and oxytocin receptors regulating glutamate release in adult striatal astrocytes

S Amato, M Averna, D Guidolin, M Pedrazzi… - International Journal of …, 2022 - mdpi.com
Background: Roles of astrocytes in the modulatory effects of oxytocin (OT) in central nervous
system are increasingly considered. Nevertheless, OT effects on gliotransmitter release …

Characterization of the AGR2 interactome uncovers new players of protein disulfide isomerase network in cancer cells

P Bouchalova, L Sommerova, D Potesil… - Molecular & Cellular …, 2022 - ASBMB
Anterior gradient 2 (AGR2) is an endoplasmic reticulum (ER)-resident protein disulfide
isomerase (PDI) known to be overexpressed in many human epithelial cancers and is …

Staphylococcus aureus Exfoliative Toxin E, Oligomeric State and Flip of P186: Implications for Its Action Mechanism

C Gismene, JE Hernandez Gonzalez… - International Journal of …, 2022 - mdpi.com
Staphylococcal exfoliative toxins (ETs) are glutamyl endopeptidases that specifically cleave
the Glu381-Gly382 bond in the ectodomains of desmoglein 1 (Dsg1) via complex action …

Tailoring the Hinge Residue at the Substrate Access Tunnel Entrance Improves the Catalytic Performance of Industrialized Nitrile Hydratase Toward 3‐Cyanopyridine

Y Xia, M Yin, L Peplowski, Z Cheng, Z Zhou - ChemistrySelect, 2022 - Wiley Online Library
Nicotinamide is a high‐value chemical that has been widely applied in various aspects of
daily life. Nitrile hydratase (NHase) is capable of carrying out biotransformation of nitriles to …

The Target Therapy Hyperbole:“KRAS (p. G12C)”—The Simplification of a Complex Biological Problem

M Chetta, A Basile, M Tarsitano, M Rivieccio, M Oro… - Cancers, 2024 - mdpi.com
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) gene variations are linked to the
development of numerous cancers, including non-small cell lung cancer (NSCLC) …

Structural Characterization of the Chlorophyllide a Oxygenase (CAO) Enzyme Through an In Silico Approach

D Dey, R Tanaka, H Ito - Journal of molecular evolution, 2023 - Springer
Chlorophyllide a oxygenase (CAO) is responsible for converting chlorophyll a to chlorophyll
b in a two-step oxygenation reaction. CAO belongs to the family of Rieske-mononuclear iron …