Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

Electrophysiology, the'gold standard'for investigating neuronal signalling, is being
challenged by a new generation of optical probes. Together with new forms of microscopy …

GABAergic interneurons play a major role in the function of the mammalian neocortex, but
their circuit connectivity is still poorly understood. We used two-photon RuBi-Glutamate …

The ability to optically image cellular transmembrane voltages at millisecond-timescale
resolutions can offer unprecedented insight into the function of living brains in behaving …

This review aims to summarize data obtained with different techniques to provide a
functional map of the local circuit connections made by neocortical neurones, a reference for …

A basic feature of the neocortex is its organization in functional, vertically oriented columns,
recurring modules of signal processing and a system of transcolumnar long-range horizontal …

To understand fine-scale structure and function of single mammalian neuronal networks, we
developed and validated a strategy to genetically target and trace monosynaptic inputs to a …

Understanding the basis of brain function requires knowledge of cortical operations over
wide-spatial scales, but also within the context of single neurons. In vivo, wide-field GCaMP …

We present a novel, all-electric approach to record and to precisely control the activity of
tens of individual presynaptic neurons. The method allows for parallel mapping of the …

Functional multineuron calcium imaging (fMCI) is a large-scale optical recording technique
that monitors the spatiotemporal pattern of action potentials, all at once, from large neuron …