Obesity, which is a worldwide epidemic, confers increased risk for multiple serious
conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular …

The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with
a dramatic decline in physical activity are the alleged main causes for this pandemic. While …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

The brain, particularly the hypothalamus, integrates input from factors that stimulate
(orexigenic) and inhibit (anorexigenic) food intake. In fish, the identification of appetite …

Leptin, the protein product of the obese (ob or Lep) gene, is a hormone synthesized by
adipocytes that signals available energy reserves to the brain, and thereby influences …

In this thematic issue on phenotyping the obesities, prominent international experts offer an
insightful and comprehensive collection of articles covering the current knowledge in the …

To assess the role of leptin on food intake regulation in goldfish, we examined the effects of
central (intracerebroventricular, ICV) and peripheral (intraperitoneal, IP) injections of …

Obesity constitutes one of the most important metabolic diseases being associated to insulin
resistance development and increased cardiovascular risk. Association between obesity …

Leptin is a key factor in the regulation of food intake and is an important factor in the
pathophysiology of obesity. However, more than a decade after the discovery of leptin in …