[HTML][HTML] LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
M Arra, G Swarnkar, K Ke, JE Otero, J Ying… - Nature …, 2020 - nature.com
The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear,
and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show …
and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show …
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review
H Crawford, M Dimitriadi, J Bassin… - … A European Journal, 2022 - Wiley Online Library
The last decade has seen an increasingly large number of studies reporting on the
development of novel small organic conjugated systems for mitochondrial imaging …
development of novel small organic conjugated systems for mitochondrial imaging …
[HTML][HTML] Natural cryoprotective and cytoprotective agents in cryopreservation: A focus on melatonin
G Marcantonini, D Bartolini, L Zatini, S Costa… - Molecules, 2022 - mdpi.com
Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental
components of the cryopreservation process. This review presents the essentials of the …
components of the cryopreservation process. This review presents the essentials of the …
Ferritinophagy‐Mediated Ferroptosis and Activation of Keap1/Nrf2/HO‐1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2 ′‐Di …
D Guan, W Zhou, H Wei, T Wang… - Oxidative medicine …, 2022 - Wiley Online Library
In metastasis of cancer cells, the epithelial‐mesenchymal transition (EMT) is prerequired.
Ferroptosis is an iron‐mediated cellular death process, but whether it involves EMT …
Ferroptosis is an iron‐mediated cellular death process, but whether it involves EMT …
Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)
FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
[HTML][HTML] Natural deep eutectic systems, an emerging class of cryoprotectant agents
This work aimed at evaluating the potential of using natural deep eutectic systems (NADES)
as cryoprotectant agents (CPAs). Several combinations between natural primary metabolites …
as cryoprotectant agents (CPAs). Several combinations between natural primary metabolites …
The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies
Excessive adiposity in an obese state is known to drive the onset of metabolic
dysregulations, mostly involving chronic immune activation and oxidative stress. Prolonged …
dysregulations, mostly involving chronic immune activation and oxidative stress. Prolonged …
Aurones: a promising scaffold to inhibit SARS-CoV-2 replication
GS Caleffi, AS Rosa, LG de Souza… - Journal of Natural …, 2023 - ACS Publications
Aurones are a small subgroup of flavonoids in which the basic C6–C3–C6 skeleton is
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …
Ovarian tissue cryopreservation and transplantation: a review on reactive oxygen species generation and antioxidant therapy
Cancer is the leading cause of death worldwide. Fortunately, the survival rate of cancer
continues to rise, owing to advances in cancer treatments. However, these treatments are …
continues to rise, owing to advances in cancer treatments. However, these treatments are …
[HTML][HTML] ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells
J Luo, Y Wang, HM Chang, H Zhu, J Yang… - Frontiers in Cell and …, 2023 - frontiersin.org
Recurrent pregnancy loss (RPL) remains an unsolved problem in obstetrics and
gynecology, and up to 50% of RPL cases are unexplained. Unexplained RPL (uRPL) is …
gynecology, and up to 50% of RPL cases are unexplained. Unexplained RPL (uRPL) is …