[HTML][HTML] LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

M Arra, G Swarnkar, K Ke, JE Otero, J Ying… - Nature …, 2020 - nature.com
The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear,
and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show …

Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review

H Crawford, M Dimitriadi, J Bassin… - … A European Journal, 2022 - Wiley Online Library
The last decade has seen an increasingly large number of studies reporting on the
development of novel small organic conjugated systems for mitochondrial imaging …

[HTML][HTML] Natural cryoprotective and cytoprotective agents in cryopreservation: A focus on melatonin

G Marcantonini, D Bartolini, L Zatini, S Costa… - Molecules, 2022 - mdpi.com
Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental
components of the cryopreservation process. This review presents the essentials of the …

Ferritinophagy‐Mediated Ferroptosis and Activation of Keap1/Nrf2/HO‐1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2 ‐Di …

D Guan, W Zhou, H Wei, T Wang… - Oxidative medicine …, 2022 - Wiley Online Library
In metastasis of cancer cells, the epithelial‐mesenchymal transition (EMT) is prerequired.
Ferroptosis is an iron‐mediated cellular death process, but whether it involves EMT …

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)

FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …

[HTML][HTML] Natural deep eutectic systems, an emerging class of cryoprotectant agents

AR Jesus, L Meneses, ARC Duarte, A Paiva - Cryobiology, 2021 - Elsevier
This work aimed at evaluating the potential of using natural deep eutectic systems (NADES)
as cryoprotectant agents (CPAs). Several combinations between natural primary metabolites …

The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies

PV Dludla, SE Mazibuko-Mbeje, TM Nyambuya… - Pharmacological …, 2019 - Elsevier
Excessive adiposity in an obese state is known to drive the onset of metabolic
dysregulations, mostly involving chronic immune activation and oxidative stress. Prolonged …

Aurones: a promising scaffold to inhibit SARS-CoV-2 replication

GS Caleffi, AS Rosa, LG de Souza… - Journal of Natural …, 2023 - ACS Publications
Aurones are a small subgroup of flavonoids in which the basic C6–C3–C6 skeleton is
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …

Ovarian tissue cryopreservation and transplantation: a review on reactive oxygen species generation and antioxidant therapy

A Najafi, E Asadi, JD Benson - Cell and Tissue Research, 2023 - Springer
Cancer is the leading cause of death worldwide. Fortunately, the survival rate of cancer
continues to rise, owing to advances in cancer treatments. However, these treatments are …

[HTML][HTML] ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells

J Luo, Y Wang, HM Chang, H Zhu, J Yang… - Frontiers in Cell and …, 2023 - frontiersin.org
Recurrent pregnancy loss (RPL) remains an unsolved problem in obstetrics and
gynecology, and up to 50% of RPL cases are unexplained. Unexplained RPL (uRPL) is …