The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

The role of vitamin D in fertility and during pregnancy and lactation: a review of clinical data

S Pilz, A Zittermann, R Obeid, A Hahn… - International journal of …, 2018 - mdpi.com
Vitamin D deficiency is common and there exists a huge gap between recommended dietary
vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is …

Endocrine disrupting chemicals impact on ovarian aging: Evidence from epidemiological and experimental evidence

T Ding, W Yan, T Zhou, W Shen, T Wang, M Li… - Environmental …, 2022 - Elsevier
Endocrine-disrupting chemicals (EDCs) are ubiquitous in daily life, but their harmful effects
on the human body have not been fully explored. Recent studies have shown that EDCs …

Ovarian aging: role of pituitary-ovarian axis hormones and ncRNAs in regulating ovarian mitochondrial activity

M Colella, D Cuomo, T Peluso, I Falanga… - Frontiers in …, 2021 - frontiersin.org
The number of mitochondria in the oocyte along with their functions (eg, energy production,
scavenger activity) decline with age progression. Such multifaceted functions support …

Obesity, insulin resistance, and hyperandrogenism mediate the link between poor diet quality and ovarian dysmorphology in reproductive-aged women

M Kazemi, BY Jarrett, H Vanden Brink, AW Lin… - Nutrients, 2020 - mdpi.com
The relationship between diet quality and ovarian morphology has biological plausibility yet
remains unclear and was therefore evaluated. In a multicenter cross-sectional analysis, four …

The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid cancer patients: a systematic review and meta-analysis

MW Piek, EL Postma, R van Leeuwaarde, JP de Boer… - Thyroid, 2021 - liebertpub.com
Introduction: Thyroid cancer is one of the most common carcinomas diagnosed in
adolescents and young adults, with a rapidly rising incidence for the past three decades …

Healthy eating index and risk of diminished ovarian reserve: a case–control study

H Ghasemi-Tehrani, G Askari, FZ Allameh, M Vajdi… - Scientific Reports, 2024 - nature.com
Diminished ovarian reserve (DOR) is associated with reduced fertility and poor reproductive
outcomes. The association between dietary patterns and DOR was not well studied. The …

Ovarian aging: mechanisms and intervention strategies

Z Zhu, W Xu, L Liu - Medical Review, 2023 - degruyter.com
Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

[HTML][HTML] Boosting mitochondrial function and metabolism in aging female germ cells with dual ROCK/ROS inhibition

WP Su, CJ Li, LT Lin, PH Lin, ZH Wen, JJC Sheu… - Biomedicine & …, 2023 - Elsevier
The decline in oocyte quality with age is an irreversible process that results in low fertility.
Reproductive aging causes an increase in oocyte aneuploidy leading to a decrease in …

[HTML][HTML] Effects of vitamin D supplementation on ovarian reserve markers in infertile women with diminished ovarian reserve

BH Bacanakgil, G İlhan, K Ohanoğlu - Medicine, 2022 - journals.lww.com
The purpose of this study was to evaluate the effects of vitamin D supplementation on
ovarian reserve markers, including serum anti-Mullerian hormone (AMH) level, follicle …