Antimicrobial treatment failure threatens our ability to control infections. In addition to
antimicrobial resistance, treatment failures are increasingly understood to derive from cells …

The use of next generation sequencing has the power to expedite the identification of drug
resistance determinants and biomarkers and was applied successfully to drug resistance …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into
several distinctive forms, each thought to represent an adaptation to specific …

When Trypanosoma brucei parasites, the causative agent of sleeping sickness, colonize the
adipose tissue, they rewire gene expression. Whether this adaptation affects population …

Differentiation between distinct stages is fundamental for the life cycle of intracellular
protozoan parasites and for transmission between hosts, requiring stringent spatial and …

Abstract Treatment failure (TF) jeopardizes the management of parasitic diseases, including
leishmaniasis. From the parasite's point of view, drug resistance (DR) is generally …

Together with vector control, chemotherapy is an essential tool for the control of visceral
leishmaniasis (VL), but its efficacy is jeopardized by growing resistance and treatment failure …

Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …