Myeloid cell-targeted therapies for solid tumours
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …
where they have a variety of functions, ranging from immunosuppressive to …
[HTML][HTML] Roles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
[HTML][HTML] Transcription factors interact with RNA to regulate genes
O Oksuz, JE Henninger, R Warneford-Thomson… - Molecular cell, 2023 - cell.com
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens
Most variants associated with complex traits and diseases identified by genome-wide
association studies (GWAS) map to noncoding regions of the genome with unknown effects …
association studies (GWAS) map to noncoding regions of the genome with unknown effects …
Tissue homeostasis and inflammation
ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …
inflammation. However, despite an abundance of data, the organizing principles of tissue …
Chemically defined cytokine-free expansion of human haematopoietic stem cells
M Sakurai, K Ishitsuka, R Ito, AC Wilkinson, T Kimura… - Nature, 2023 - nature.com
Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …
immune systems after transplantation and can be used as a curative cell therapy for a variety …
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
M Tsukasaki, H Takayanagi - Nature Reviews Immunology, 2019 - nature.com
In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
[HTML][HTML] MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Characterization of cell fate probabilities in single-cell data with Palantir
Single-cell RNA sequencing studies of differentiating systems have raised fundamental
questions regarding the discrete versus continuous nature of both differentiation and cell …
questions regarding the discrete versus continuous nature of both differentiation and cell …
[HTML][HTML] Single-cell RNA-seq denoising using a deep count autoencoder
Single-cell RNA sequencing (scRNA-seq) has enabled researchers to study gene
expression at a cellular resolution. However, noise due to amplification and dropout may …
expression at a cellular resolution. However, noise due to amplification and dropout may …