In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

Genome architecture plays a pivotal role in gene regulation. The use of high-throughput
methods for chromatin profiling and 3-D interaction mapping provide rich experimental data …

Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein
1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for …

Understanding the spatial organization of the genome in the cell nucleus is one of the
current grand challenges in biophysics. Certain biochemical—or epigenetic—marks that are …

The regulation of chromatin biology ultimately depends on the manipulation of its smallest
subunit, the nucleosome. The proteins that bind and operate on the nucleosome do so …

Chromatin conformation is dynamic and heterogeneous with respect to nucleosome
positions, which can be changed by chromatin remodeling complexes in the cell. These …

The mammalian epigenome contains thousands of heterochromatin nanodomains (HNDs)
marked by di-and trimethylation of histone H3 at lysine 9 (H3K9me2/3), which have a typical …

Heterochromatin is a conserved feature of eukaryotic chromosomes with central roles in
regulation of gene expression and maintenance of genome stability. Heterochromatin …

Communication between distantly spaced genomic regions is one of the key features of
gene regulation in eukaryotes. Chromatin per se can stimulate efficient enhancer-promoter …

The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble
heterochromatin-like domains/complexes outside canonical constitutively heterochromatic …