Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Multiple system atrophy (MSA) is a devastating and fatal neurodegenerative disorder. The
clinical presentation of this disease is highly variable, with parkinsonism, cerebellar ataxia …

Multiple system atrophy (MSA) is a rare oligodendroglial α-synucleinopathy characterized by
neurodegeneration in striatonigral and olivopontocerebellar regions and autonomic brain …

Neurological diseases refer to the diseases that target the nervous system (brain, spine or
nerves). They are the second leading cause of death, and the first cause of severe long-term …

Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized
by a variable combination of parkinsonism, cerebellar impairment, and autonomic …