In ageing populations, neurodegenerative diseases increase in prevalence, exacting an
enormous toll on individuals and their communities. Multiple complementary experimental …

Progress in aging research is now rapid, and surprisingly, studies in a single-celled
eukaryote are a driving force. The genetic modulators of replicative life span in yeast are …

Huntington's disease is caused by an abnormally long polyglutamine tract in the huntingtin
protein. This leads to the generation and deposition of N-terminal exon1 fragments of the …

The accumulation of misfolded proteins in intracellular amyloid inclusions, typical of many
neurodegenerative disorders including Huntington's and prion disease, is thought to occur …

Proteins do not function in isolation; it is their interactions with one another and also with
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …

Protein misfolding is intimately associated with devastating human neurodegenerative
diseases, including Alzheimer's, Huntington's, and Parkinson's. Although disparate in their …

α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative
diseases, including Parkinson's disease, whose pathobiology is conserved from yeast to …

Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is
a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally …

Mutations are at the root of many human diseases. Still, we largely do not exactly
understand how they trigger pathogenesis. One, more recent, hypothesis has been that they …

Protein phosphorylation is a prevalent and ubiquitous mechanism of regulation. Kinases are
popular drug targets, but identifying selective phosphatase inhibitors has been challenging …