Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Aspects of the tumor microenvironment involved in immune resistance and drug resistance
K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
Pancreatic cancer stroma: an update on therapeutic targeting strategies
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …
the Western world with limited therapeutic options and dismal long-term survival. The …
Tumor microenvironment
B Arneth - Medicina, 2019 - mdpi.com
Background and Objectives: The tumor microenvironment has been widely implicated in
tumorigenesis because it harbors tumor cells that interact with surrounding cells through the …
tumorigenesis because it harbors tumor cells that interact with surrounding cells through the …
Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs
ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …
Crosstalk of inflammatory cytokines within the breast tumor microenvironment
O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
The pros and cons of mesenchymal stem cell-based therapies
A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …
scientists and physicians to focus their attention on regenerative medicine and broadly …
Tumor-associated stromal cells as key contributors to the tumor microenvironment
KM Bussard, L Mutkus, K Stumpf… - Breast Cancer …, 2016 - Springer
The tumor microenvironment is a heterogeneous population of cells consisting of the tumor
bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are …
bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are …
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …
improving treatment outcomes has focused on modulating radiation-induced biological …