The ENCODE project has reported that at least 80% of the human genome is biologically
active, yet only a small part of human DNA encodes for protein. The massive amount of RNA …

MicroRNAs (miRNAs) are short non-coding RNAs with a length of∼ 22 nucleotides,
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Background Accumulating evidence shows that long noncoding RNAs (lncRNAs) are
important regulator molecules involved in diverse biological processes. Acquired drug …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily that can initiate the apoptosis pathway by binding to its associated death …

Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …

Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment.
Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of …

Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

Purpose: Concomitant genetic alterations could account for transient clinical responses to
tyrosine kinase inhibitors of the EGF receptor (EGFR) in patients harboring activating EGFR …

Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor
growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the …