Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Template-based analysis of multi-parametric MRI data of the spinal cord sets the foundation
for standardization and reproducibility, thereby helping the discovery of new biomarkers of …

Quantifying spinal cord (SC) atrophy in neurodegenerative and traumatic diseases brings
important diagnosis and prognosis information for the clinician. We recently developed the …

Background Diagnostic uncertainty in ALS has serious management implications and
delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden …

Segmenting the spinal cord contour is a necessary step for quantifying spinal cord atrophy in
various diseases. Delineating gray matter (GM) and white matter (WM) is also useful for …

Background and purpose Assessing survival is a critical issue in patients with amyotrophic
lateral sclerosis (ALS). Neuroimaging seems to be promising in the assessment of disease …

Spinal cord tumour is an abnormal growth of cells in and around the spinal cord. Detecting
spinal cord tumours is a very crucial process. Identifying the tumour from MRI is difficult …

Abstract Study design Method development. Objectives To develop a reliable protocol for
automatic segmentation of Thoracolumbar spinal cord using MRI based on K-means …

Purpose To propose a robust and accurate method for straightening magnetic resonance
(MR) images of the spinal cord, based on spinal cord segmentation, that preserves spinal …