Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …

Objective The gut microbiota plays a key role in modulating host immune response. We
conducted a prospective, observational study to examine gut microbiota composition in …

Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …

The interferon (IFN) response is the major early innate immune response against invading
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …

The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …

Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …

Host genetic and environmental factors including age, biological sex, diet, geographical
location, microbiome composition and metabolites converge to influence innate and …