Metabolism and epigenetics at the heart of T cell function
L Soriano-Baguet, D Brenner - Trends in immunology, 2023 - cell.com
T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …
Function and mechanism of histone β-hydroxybutyrylation in health and disease
T Zhou, X Cheng, Y He, Y Xie, F Xu, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that
affect chromatin-associated nuclear processes without altering the DNA sequence. With the …
affect chromatin-associated nuclear processes without altering the DNA sequence. With the …
[HTML][HTML] The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders
Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …
of the network, resulting in alterations in brain function and behavior. It is traditionally …
Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription–replication conflicts caused by replication stress
S Hao, Y Wang, Y Zhao, W Gao, W Cui… - Nucleic Acids …, 2022 - academic.oup.com
The reversible post-translational modification (PTM) of proteins plays an important role in
many cellular processes. Lysine crotonylation (Kcr) is a newly identified PTM, but its …
many cellular processes. Lysine crotonylation (Kcr) is a newly identified PTM, but its …
[HTML][HTML] Crotonylation and disease: Current progress and future perspectives
P Yang, Y Qin, L Zeng, Y He, Y Xie, X Cheng… - Biomedicine & …, 2023 - Elsevier
Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …
modification in 2011. In recent years, prominent progress has been made in the study of …
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression
G Mas, N Man, Y Nakata, C Martinez-Caja, D Karl… - The Journal of clinical …, 2024 - jci.org
During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to
produce myeloid and lymphoid effector cells, a response that is critical against infection or …
produce myeloid and lymphoid effector cells, a response that is critical against infection or …
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease …
W Rungratanawanich, JW Ballway, X Wang… - Pharmacology & …, 2023 - Elsevier
Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …
influenced by environmental factors and metabolic changes to modulate gene activity with …
Nuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
L Dang, X Cao, T Zhang, Y Sun, S Tian… - Journal of the …, 2022 - journals.lww.com
Background Emerging evidence indicates that epigenetic modulation of gene expression
plays a key role in the progression of autosomal dominant polycystic kidney disease …
plays a key role in the progression of autosomal dominant polycystic kidney disease …
Epigenetic meets metabolism: novel vulnerabilities to fight cancer
Histones undergo a plethora of post-translational modifications (PTMs) that regulate
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …
Beyond the tail: the consequence of context in histone post-translational modification and chromatin research
EN Weinzapfel, KN Fedder-Semmes… - Biochemical …, 2024 - portlandpress.com
The role of histone post-translational modifications (PTMs) in chromatin structure and
genome function has been the subject of intense debate for more than 60 years. Though …
genome function has been the subject of intense debate for more than 60 years. Though …