Vascularization is the key challenge in tissue engineering

EC Novosel, C Kleinhans, PJ Kluger - Advanced drug delivery reviews, 2011 - Elsevier
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

Cell sheet engineering for heart tissue repair

S Masuda, T Shimizu, M Yamato, T Okano - Advanced drug delivery …, 2008 - Elsevier
Recently, myocardial tissue engineering has emerged as one of the most promising
therapies for patients suffering from severe heart failure. Nevertheless, conventional …

[HTML][HTML] Cell sheet technology as an engineering-based approach to bone regeneration

Q You, M Lu, Z Li, Y Zhou, C Tu - International Journal of …, 2022 - ncbi.nlm.nih.gov
Bone defects that are congenital or the result of infection, malignancy, or trauma represent a
challenge to the global healthcare system. To address this issue, multiple research groups …

[HTML][HTML] Vascular smooth muscle cells activate PI3K/Akt pathway to attenuate myocardial ischemia/reperfusion-induced apoptosis and autophagy by secreting bFGF

G Ye, Q Fu, L Jiang, Z Li - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Background Vascular smooth muscle cells (VSMCs) has been reported to be implicated in
atherosclerotic plaque instability and rupture. Recently, it has been demonstrated that …

Bulk poly (N-isopropylacrylamide)(PNIPAAm) thermoresponsive cell culture platform: toward a new horizon in cell sheet engineering

A Choi, KD Seo, H Yoon, SJ Han, DS Kim - Biomaterials science, 2019 - pubs.rsc.org
Although a conventional method of utilizing thermoresponsive grafted poly (N-
isopropylacrylamide)(PNIPAAm) enables the harvest of a healthy confluent cell-to-cell …

Dynamically cell separating thermo-functional biointerfaces with densely packed polymer brushes

K Nagase, A Kimura, T Shimizu, K Matsuura… - Journal of Materials …, 2012 - pubs.rsc.org
Poly (N-isopropylacrylamide)(PIPAAm) brush grafted glass surfaces with various brush
lengths were prepared as cell separating intelligent interfaces through a surface-initiated …

Present and future perspectives on cell sheet‐based myocardial regeneration therapy

Y Sawa, S Miyagawa - BioMed Research International, 2013 - Wiley Online Library
Heart failure is a life‐threatening disorder worldwide and many papers reported about
myocardial regeneration through surgical method induced by LVAD, cellular …

Hydrophobized thermoresponsive copolymer brushes for cell separation by multistep temperature change

K Nagase, Y Hatakeyama, T Shimizu… - …, 2013 - ACS Publications
For preparing a thermally modulated biointerface that separates cells without the
modification of cell surfaces for regenerative medicine and tissue engineering, poly (N …

Vascularizing the heart

PR Riley, N Smart - Cardiovascular research, 2011 - academic.oup.com
As the developing heart grows and the chamber walls thicken, passive diffusion of oxygen
and nutrients is replaced by a vascular plexus which remodels and expands to form a …

Tissue-engineered cardiac constructs for cardiac repair

S Miyagawa, M Roth, A Saito, Y Sawa… - The Annals of thoracic …, 2011 - Elsevier
Several recent basic research studies have described surgical methods for cardiac repair
using tissue cardiomyoplasty. This review summarizes recent advances in cardiac repair …