Fatty acids (FFAs) are important biological molecules that serve as a major energy source
and are key components of biological membranes. In addition, FFAs play important roles in …

Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to
increase insulin secretion either directly target β-cells or indirectly target gastrointestinal …

An aging world population exposed to a sedentary life style is currently plagued by chronic
metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an …

Adipose tissue can be divided anatomically, histologically, and functionally into two major
entities white and brown adipose tissues (WAT and BAT, respectively). WAT is the primary …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors involved
in the regulation of almost all known physiological processes. Dysfunctions of GPCR …

Obesity-associated type 2 diabetes mellitus (T2DM) entails insulin resistance and loss of β-
cell mass. Adipose tissue mitochondrial dysfunction is emerging as a key component in the …

One approach of modern drug discovery is to identify agents that enhance or diminish signal
transduction cascades in various cell types and tissues by modulating the activity of GPCRs …

Objectives Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through
an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which …

G-protein coupled receptors 40 and 120 (GPR40 and GPR120) are increasingly emerging
as potential therapeutic targets for the treatment of altered glucose homeostasis, and their …

Abstract Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver
disease and is associated with metabolic dysregulation. Although G protein-coupled …