Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel
In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …
The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases
Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …
has different physiological functions including inhibiting the release of insulin and glucagon …
The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM)
Abstract Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and
released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a …
released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a …
A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
RV Sionov, R Ahdut-HaCohen - Biomedicines, 2023 - mdpi.com
Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …
Defective autophagy and autophagy activators in Myasthenia Gravis: a rare entity and unusual scenario
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that
results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs …
results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs …
Dysregulation of pancreatic β-cell autophagy and the risk of type 2 diabetes
Autophagy is an essential degradation process that removes abnormal cellular components,
maintains homeostasis within cells, and provides nutrition during starvation. Activated …
maintains homeostasis within cells, and provides nutrition during starvation. Activated …
Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue
Parkinson's disease (PD) is a progressive neurodegenerative disease of the brain due to
degeneration of dopaminergic neurons in the substantia nigra (SN). Glycogen synthase …
degeneration of dopaminergic neurons in the substantia nigra (SN). Glycogen synthase …
Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities
C Dai, H Zhang, Z Zheng, CG Li, M Ma, H Gao… - Frontiers in …, 2024 - frontiersin.org
Introduction Macrophage-mediated inflammatory response may have crucial roles in the
pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a …
pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a …
Interplay between Senescence and Macrophages in Diabetic Cardiomyopathy: A Review of the Potential Role of GDF-15 and Klotho
GM Almohaimeed, AS Alonazi, AF Bin Dayel… - Biomedicines, 2024 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a critical health problem, with 700 million diagnoses
expected worldwide by 2045. Uncontrolled high blood glucose levels can lead to serious …
expected worldwide by 2045. Uncontrolled high blood glucose levels can lead to serious …