As dense connective tissues connecting bone to muscle and bone to bone, respectively,
tendon and ligament (T/L) arise from the somitic mesoderm, originating in a recently …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is
responsible for piloerection (" goosebumps"). We show that stem cells in the bulge deposit …

Sutures separate the flat bones of the skull and enable coordinated growth of the brain and
overlying cranium. The coronal suture is most commonly fused in monogenic …

Topographical cues from the extracellular microenvironment can influence cellular activity
including proliferation and differentiation. Information on the effects of material topography …

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …

Injured tendons heal slowly and often result in the formation of mechanically and functionally
inferior fibrotic scar tissue or fibrous adhesions. This study investigated the use of tendon …

The molecular programme underlying tendon development has not been fully identified.
Interactions with components of the musculoskeletal system are important for limb tendon …

Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …

Most of the exogenous biomaterials for tendon repair have limitations including lower
capacity for inducing cell proliferation and differentiation, poorer biocompatibility and …