The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have …

The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well
defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed …

Innate immunity, cell death and inflammation underpin many aspects of health and disease.
Upon sensing pathogens, pathogen-associated molecular patterns or damage-associated …

Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid
cells, have gained increasing attention for their role in the fine tuning of both innate and …

C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition
receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties …

Gaucher disease (GD) is the most common lysosomal storage disease caused by recessive
mutations in the degrading enzyme of β-glucosylceramide (β-GlcCer). However, it remains …