Recent advances in imaging, modeling, and computing have rapidly expanded our
capabilities to model hemodynamics in the large vessels (heart, arteries, and veins). This …

Shear-induced platelet activation is one of the critical outcomes when blood is exposed to
elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus …

The hemodynamics within the aorta of five healthy humans were investigated to gain insight
into the complex helical flow patterns that arise from the existence of asymmetries in the …

The advent of implantable blood-recirculating devices such as left ventricular assist devices
and prosthetic heart valves provides a viable therapy for patients with end-stage heart failure …

Patients with ventricular assist devices still suffer from high rates of adverse events. Since
many of these complications are linked to the flow field within the pump, optimization of the …

Computational fluid dynamics (CFD) models have become very effective tools for predicting
the flow field within the carotid bifurcation, and for understanding the relationship between …

Here we present a study on the impact of assumptions on image-based hemodynamic
simulations of healthy carotid bifurcations. In particular, we evaluate to which extent …

Patients who receive prosthetic heart valve (PHV) implants require mandatory
anticoagulation medication after implantation due to the thrombogenic potential of the valve …

The purpose of this study was to investigate the influence of non-physiological high shear
stress on activation and shedding of platelet GP IIb/IIIa receptors. The healthy donor blood …

Thrombus formation is a major concern for recipients of mechanical heart valves (MHVs),
which requires them to take anticoagulant drugs for the rest of their lives. Bioprosthetic heart …