Live cell microscopy: From image to insight
AP Cuny, FP Schlottmann, JC Ewald, S Pelet… - Biophysics …, 2022 - pubs.aip.org
Live-cell microscopy is a powerful tool that can reveal cellular behavior as well as the
underlying molecular processes. A key advantage of microscopy is that by visualizing …
underlying molecular processes. A key advantage of microscopy is that by visualizing …
Impact of hydrogen peroxide on protein synthesis in yeast
Cells must be able to respond and adapt to different stress conditions to maintain normal
function. A common response to stress is the global inhibition of protein synthesis. Protein …
function. A common response to stress is the global inhibition of protein synthesis. Protein …
Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC
F Padovani, B Mairhörmann, P Falter-Braun… - BMC biology, 2022 - Springer
Background High-throughput live-cell imaging is a powerful tool to study dynamic cellular
processes in single cells but creates a bottleneck at the stage of data analysis, due to the …
processes in single cells but creates a bottleneck at the stage of data analysis, due to the …
What is stress? A systems perspective
The term “stress” is used to describe important phenomena at multiple levels of biological
organization, but finding a general and rigorous definition of the concept has proven …
organization, but finding a general and rigorous definition of the concept has proven …
ROS networks: designs, aging, Parkinson's disease and precision therapies
How the network around ROS protects against oxidative stress and Parkinson's disease
(PD), and how processes at the minutes timescale cause disease and aging after decades …
(PD), and how processes at the minutes timescale cause disease and aging after decades …
Excessive rDNA transcription drives the disruption in nuclear homeostasis during entry into senescence in budding yeast
Budding yeast cells undergo a limited number of divisions before they enter senescence
and die. Despite recent mechanistic advances, whether and how molecular events are …
and die. Despite recent mechanistic advances, whether and how molecular events are …
Distributed and dynamic intracellular organization of extracellular information
AA Granados, JMJ Pietsch… - Proceedings of the …, 2018 - National Acad Sciences
Although cells respond specifically to environments, how environmental identity is encoded
intracellularly is not understood. Here, we study this organization of information in budding …
intracellularly is not understood. Here, we study this organization of information in budding …
DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis
Automating the extraction of meaningful temporal information from sequences of microscopy
images represents a major challenge to characterize dynamical biological processes. So far …
images represents a major challenge to characterize dynamical biological processes. So far …
Multiple inputs ensure yeast cell size homeostasis during cell cycle progression
C Garmendia-Torres, O Tassy, A Matifas, N Molina… - Elife, 2018 - elifesciences.org
Coordination of cell growth with division is essential for proper cell function. In budding
yeast, although some molecular mechanisms responsible for cell size control during G1 …
yeast, although some molecular mechanisms responsible for cell size control during G1 …
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-
effect relationships are not well understood. We show that most yeast cells arrest in G1 …
effect relationships are not well understood. We show that most yeast cells arrest in G1 …