Clinical actionability of molecular targets in endometrial cancer

ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Integrative drug screening and multiomic characterization of patient-derived bladder Cancer Organoids Reveal Novel Molecular correlates of Gemcitabine Response

NM Merrill, SD Kaffenberger, L Bao, N Vandecan… - European Urology, 2024 - Elsevier
Background and objective Predicting response to therapy for each patient's tumor is critical
to improving long-term outcomes for muscle-invasive bladder cancer. This study aims to …

[HTML][HTML] Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors

PW Harms, ME Verhaegen, K Hu, SM Hrycaj… - Modern Pathology, 2022 - Elsevier
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …

Genome‐wide mutation analysis in precancerous lesions of endometrial carcinoma

L Li, P Yue, Q Song, TT Yen, S Asaka… - The Journal of …, 2021 - Wiley Online Library
Clinicopathological evidence supports endometrial atypical hyperplasia (AH) or endometrial
intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), the most …

Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes

L Lazo de la Vega, N Bick, K Hu, SE Rahrig… - Modern …, 2020 - nature.com
Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at
many anatomic sites, the driving molecular alterations underlying their progression from …

Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis

U Singhal, S Nallandhighal, JJ Tosoian, K Hu… - Nature …, 2024 - nature.com
Localized prostate cancer is frequently composed of multiple spatially distinct tumors with
significant inter-and intra-tumoral molecular heterogeneity. This genomic diversity gives rise …

CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer

FA Faisal, S Murali, H Kaur, T Vidotto, LB Guedes… - Clinical Cancer …, 2020 - AACR
Purpose: The potential biological determinants of aggressive prostate cancer in African
American (AA) men are unknown. Here we characterize prostate cancer genomic alterations …

Molecular evaluation of low-grade low-stage endometrial cancer with and without recurrence

CE Matrai, K Ohara, KW Eng, SM Glynn… - International Journal …, 2022 - journals.lww.com
Low-grade, low-stage endometrioid carcinomas (LGLS EC) demonstrate 5-yr survival rates
up to 95%. However, a small subset of these tumors recur, and little is known about …

Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

VF Bonazzi, O Kondrashova, D Smith, K Nones… - Genome Medicine, 2022 - Springer
Background Endometrial cancer (EC) is a major gynecological cancer with increasing
incidence. It comprises four molecular subtypes with differing etiology, prognoses, and …

Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal …

PW Harms, M Runge, MP Chan, CJ Liu, Z Qin… - Modern Pathology, 2024 - Elsevier
Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features
intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such …