Clinical actionability of molecular targets in endometrial cancer
ME Urick, DW Bell - Nature Reviews Cancer, 2019 - nature.com
Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …
worldwide. Disease mortality and the increasing number of new diagnoses make …
Integrative drug screening and multiomic characterization of patient-derived bladder Cancer Organoids Reveal Novel Molecular correlates of Gemcitabine Response
NM Merrill, SD Kaffenberger, L Bao, N Vandecan… - European Urology, 2024 - Elsevier
Background and objective Predicting response to therapy for each patient's tumor is critical
to improving long-term outcomes for muscle-invasive bladder cancer. This study aims to …
to improving long-term outcomes for muscle-invasive bladder cancer. This study aims to …
[HTML][HTML] Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors
PW Harms, ME Verhaegen, K Hu, SM Hrycaj… - Modern Pathology, 2022 - Elsevier
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …
Genome‐wide mutation analysis in precancerous lesions of endometrial carcinoma
L Li, P Yue, Q Song, TT Yen, S Asaka… - The Journal of …, 2021 - Wiley Online Library
Clinicopathological evidence supports endometrial atypical hyperplasia (AH) or endometrial
intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), the most …
intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), the most …
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes
Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at
many anatomic sites, the driving molecular alterations underlying their progression from …
many anatomic sites, the driving molecular alterations underlying their progression from …
Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis
Localized prostate cancer is frequently composed of multiple spatially distinct tumors with
significant inter-and intra-tumoral molecular heterogeneity. This genomic diversity gives rise …
significant inter-and intra-tumoral molecular heterogeneity. This genomic diversity gives rise …
CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer
Purpose: The potential biological determinants of aggressive prostate cancer in African
American (AA) men are unknown. Here we characterize prostate cancer genomic alterations …
American (AA) men are unknown. Here we characterize prostate cancer genomic alterations …
Molecular evaluation of low-grade low-stage endometrial cancer with and without recurrence
CE Matrai, K Ohara, KW Eng, SM Glynn… - International Journal …, 2022 - journals.lww.com
Low-grade, low-stage endometrioid carcinomas (LGLS EC) demonstrate 5-yr survival rates
up to 95%. However, a small subset of these tumors recur, and little is known about …
up to 95%. However, a small subset of these tumors recur, and little is known about …
Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer
VF Bonazzi, O Kondrashova, D Smith, K Nones… - Genome Medicine, 2022 - Springer
Background Endometrial cancer (EC) is a major gynecological cancer with increasing
incidence. It comprises four molecular subtypes with differing etiology, prognoses, and …
incidence. It comprises four molecular subtypes with differing etiology, prognoses, and …
Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal …
PW Harms, M Runge, MP Chan, CJ Liu, Z Qin… - Modern Pathology, 2024 - Elsevier
Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features
intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such …
intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such …