Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Computational modelling of cell spreading and tissue regeneration in porous scaffolds

BG Sengers, M Taylor, CP Please, ROC Oreffo - Biomaterials, 2007 - Elsevier
Improved biological and mechanical functionality of musculoskeletal tissue-engineered
constructs is required for clinical application, which can only be achieved by comprehensive …

Biodendrimer-based hydrogel scaffolds for cartilage tissue repair

SHM Söntjens, DL Nettles, MA Carnahan… - …, 2006 - ACS Publications
Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of
cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated …

EDC/NHS-crosslinked type II collagen-chondroitin sulfate scaffold: characterization and in vitro evaluation

H Cao, SY Xu - Journal of Materials Science: Materials in Medicine, 2008 - Springer
Three-dimensional biodegradable porous type II collagen scaffolds are interesting materials
for cartilage tissue engineering. This study reports the preparation of porous type II collagen …

Tuning tissue growth with scaffold degradation in enzyme-sensitive hydrogels: a mathematical model

U Akalp, SJ Bryant, FJ Vernerey - Soft matter, 2016 - pubs.rsc.org
Despite tremendous advances in the field of tissue engineering, a number of obstacles
remain that hinder its successful translation to the clinic. One challenge that relates to the …

Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion

M Rijsbergen, B van Rietbergen, V Barthelemy… - PLoS …, 2018 - journals.plos.org
Spinal fusion is a standard surgical treatment for patients suffering from low back pain
attributed to disc degeneration. However, results are somewhat variable and unpredictable …

Poly (lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering

NR Mercier, HR Costantino, MA Tracy, LJ Bonassar - Biomaterials, 2005 - Elsevier
This study demonstrates the use of biodegradable poly (lactide-co-glycolide)(PLG)
microspheres as a moldable scaffold for cartilage tissue engineering. Chondrocytes were …

Heterogeneity is key to hydrogel-based cartilage tissue regeneration

SL Sridhar, MC Schneider, S Chu, G De Roucy… - Soft Matter, 2017 - pubs.rsc.org
Degradable hydrogels have been developed to provide initial mechanical support to
encapsulated cells while facilitating the growth of neo-tissues. When cells are encapsulated …

Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling

LE Niklason, AT Yeh, EA Calle, Y Bai… - Proceedings of the …, 2010 - National Acad Sciences
Many investigators have engineered diverse connective tissues having good mechanical
properties, yet few tools enable a global understanding of the associated formation of …

Nanostructured injectable cell microcarriers for tissue regeneration

Z Zhang, TW Eyster, PX Ma - Nanomedicine, 2016 - Taylor & Francis
Biodegradable polymer microspheres have emerged as cell carriers for the regeneration
and repair of irregularly shaped tissue defects due to their injectability, controllable …