The reservoir of latent HIV

J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

The initial interplay between HIV and mucosal innate immunity

V Caputo, M Libera, S Sisti, B Giuliani… - Frontiers in …, 2023 - frontiersin.org
Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and
despite significant efforts that have been put into studying the pathogenesis of HIV infection …

[HTML][HTML] COVID-19 virulence in aged patients might be impacted by the host cellular microRNAs abundance/profile

S Fulzele, B Sahay, I Yusufu, TJ Lee, A Sharma… - Aging and …, 2020 - ncbi.nlm.nih.gov
The World health organization (WHO) declared Coronavirus disease 2019 (COVID-19) a
global pandemic and a severe public health crisis. Drastic measures to combat COVID-19 …

[HTML][HTML] Regulation of STING activity in DNA sensing by ISG15 modification

C Lin, EO Kuffour, NV Fuchs, CGW Gertzen, J Kaiser… - Cell Reports, 2023 - cell.com
Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic
GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal …

From entry to egress: strategic exploitation of the cellular processes by HIV-1

P Ramdas, AK Sahu, T Mishra, V Bhardwaj… - Frontiers in …, 2020 - frontiersin.org
HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …

IP6‐stabilised HIV capsids evade cGAS/STING‐mediated host immune sensing

G Papa, A Albecka, D Mallery, M Vaysburd… - EMBO …, 2023 - embopress.org
HIV‐1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of
delivering its genome into the host nucleus. Here, we show that viruses that are unable to …

Revisiting regulated cell death responses in viral infections

DAB Rex, TS Keshava Prasad… - International journal of …, 2022 - mdpi.com
The fate of a viral infection in the host begins with various types of cellular responses, such
as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and …

The emerging role of RNA modifications in the regulation of antiviral innate immunity

J Tong, W Zhang, Y Chen, Q Yuan, NN Qin… - Frontiers in …, 2022 - frontiersin.org
Posttranscriptional modifications have been implicated in regulation of nearly all biological
aspects of cellular RNAs, from stability, translation, splicing, nuclear export to localization …

Inflammasomes as mediators of inflammation in HIV-1 infection

AK Min, T Fortune, N Rodriguez, E Hedge… - Translational …, 2023 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) infection is a chronic disease without a known
cure. The advent of effective antiretroviral therapy (ART) has enabled people with HIV …

Toll-like receptor response to human immunodeficiency virus type 1 or co-infection with hepatitis B or C virus: an overview

MEH Kayesh, M Kohara… - International Journal of …, 2023 - mdpi.com
Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors that
play important roles in the early detection of pathogen-associated molecular patterns and …