The neural basis of psychedelic action

AC Kwan, DE Olson, KH Preller, BL Roth - Nature Neuroscience, 2022 - nature.com
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

MK Doss, M Považan, MD Rosenberg… - Translational …, 2021 - nature.com
Psilocybin has shown promise for the treatment of mood disorders, which are often
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …

[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies

KAA Andersen, R Carhart‐Harris… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective To conduct a systematic review of modern‐era (post‐millennium) clinical studies
assessing the therapeutic effects of serotonergic psychedelics drugs for mental health …

The therapeutic potential of psilocybin

H Lowe, N Toyang, B Steele, H Valentine, J Grant, A Ali… - Molecules, 2021 - mdpi.com
The psychedelic effects of some plants and fungi have been known and deliberately
exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal …

Default mode network modulation by psychedelics: a systematic review

JJ Gattuso, D Perkins, S Ruffell… - International Journal …, 2023 - academic.oup.com
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grouping of interconnected brain …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

MW Johnson, PS Hendricks, FS Barrett… - Pharmacology & …, 2019 - Elsevier
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …

[HTML][HTML] Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

RL Carhart-Harris, L Roseman, M Bolstridge… - Scientific reports, 2017 - nature.com
Psilocybin with psychological support is showing promise as a treatment model in psychiatry
but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and …