Mutational pressure drives enhanced release of proteasome-generated public CD8+ T cell epitopes from SARS-CoV-2 RBD of Omicron and its current lineages

AA Kudriaeva, IO Butenko, GA Saratov, M Ri… - medRxiv, 2024 - medrxiv.org
The COVID-19 pandemic was the most dramatic in the newest history with nearly 7 million
deaths and global impact on mankind. Here we report binding index of 305 HLA class I …

The 3.6 Å Resolution Cryo-EM Structure of the Outer Heptameric α-Ring of Human 26S Immunoproteasome in the Preactivation State

GA Saratov, TN Baymukhametov, AL Konevega… - Russian Journal of …, 2024 - Springer
Objective: The 26S proteasome is a unique multicatalytic proteinase complex, which,
together with the ubiquitination system, provides controlled degradation of most intracellular …