Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

The β‐tubulins are microtubule components encoded by a multigene family, which produces
slightly different proteins with complex expression patterns. Several widely used anticancer …

The development of resistance to paclitaxel in tumors is one of the most significant obstacles
to successful therapy. Overexpression of the βIII-tubulin isotype has been associated with …

Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Graafian ovarian follicles consist of follicular fluid, one single mature oocyte, and several
hundred thousands of granulosa cells (GCs). Until now, luteinizing GCs have been …

We hypothesize that different routes of administration may lead to altered pharmacokinetics/
pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to …

Microtubule-targeting agents, such as taxanes and epothilones, block mitosis and cell
proliferation by targeting the dynamics of the cytoskeleton. The taxanes are widely used for …

Docetaxel is one of the most active drugs used to treat breast cancer. The cellular target of
docetaxel is the microtubule, specifically the β‐tubulin subunit, that comprises a series of …