Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …

Abstract Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis,
extracellular matrix organisation, cholesterol distribution, cell migration and signaling …

Pancreatic ductal adenocarcinoma (PDA) ranks fourth among cancer related deaths. The
disappointing 5-year survival rate of below 5% stems from drug resistance to all known …

Breast cancer is one of the most common cancers with greater than 1,300,000 cases and
450,000 deaths each year worldwide. The development of breast cancer involves a …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Adenocarcinoma is a common type of malignant tumor, originating from glandular epithelial
cells in various organs, such as pancreas, breast, lung, stomach, colon, rectus, and prostate …

Nab-paclitaxel, a nanoparticle conjugate of paclitaxel to human albumin, exhibits efficacy in
pancreatic cancer, non–small cell lung cancer and breast cancer. However, there is a lack of …

Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …