Biosynthesis and export of bacterial lipopolysaccharides

C Whitfield, MS Trent - Annual review of biochemistry, 2014 - annualreviews.org
Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

Lipid A modification systems in gram-negative bacteria

CRH Raetz, CM Reynolds, MS Trent… - Annu. Rev …, 2007 - annualreviews.org
The lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane of
most gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic …

[HTML][HTML] Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Lipopolysaccharide: Biosynthetic pathway and structure modification

X Wang, PJ Quinn - Progress in lipid research, 2010 - Elsevier
Lipopolysaccharide that constitutes the outer leaflet of the outer membrane of most Gram-
negative bacteria is referred to as an endotoxin. It is comprised of a hydrophilic …

Flexibility in the ABC transporter MsbA: Alternating access with a twist

A Ward, CL Reyes, J Yu, CB Roth… - Proceedings of the …, 2007 - National Acad Sciences
ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a
wide variety of substrates across cellular membranes and are conserved from bacteria to …

Bacterial strategies of resistance to antimicrobial peptides

HS Joo, CI Fu, M Otto - … of the Royal Society B: Biological …, 2016 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …

[HTML][HTML] Recognition of lipid A variants by the TLR4-MD-2 receptor complex

N Maeshima, RC Fernandez - Frontiers in cellular and infection …, 2013 - frontiersin.org
Lipopolysaccharide (LPS) is a component of the outer membrane of almost all Gram-
negative bacteria and consists of lipid A, core sugars, and O-antigen. LPS is recognized by …

Invited review: diversity of endotoxin and its impact on pathogenesis

MS Trent, CM Stead, AX Tran… - Journal of endotoxin …, 2006 - journals.sagepub.com
Lipopolysaccharide or LPS is localized to the outer leaflet of the outer membrane and serves
as the major surface component of the bacterial cell envelope. This remarkable glycolipid is …

Modulating the innate immune response by combinatorial engineering of endotoxin

BD Needham, SM Carroll, DK Giles… - Proceedings of the …, 2013 - National Acad Sciences
Despite its highly inflammatory nature, LPS is a molecule with remarkable therapeutic
potential. Lipid A is a glycolipid that serves as the hydrophobic anchor of LPS and …

Endotoxins: lipopolysaccharides of gram-negative bacteria

X Wang, PJ Quinn - Endotoxins: structure, function and recognition, 2010 - Springer
Endotoxin refers lipopolysaccharide that constitutes the outer leaflet of the outer membrane
of most Gram-negative bacteria. Lipopolysaccharide is comprised of a hydrophilic …