Latency and lytic replication in Epstein–Barr virus-associated oncogenesis

C Münz - Nature Reviews Microbiology, 2019 - nature.com
Epstein–Barr virus (EBV) was the first tumour virus identified in humans. The virus is
primarily associated with lymphomas and epithelial cell cancers. These tumours express …

Epstein–Barr virus and cancer

PJ Farrell - Annual Review of Pathology: Mechanisms of …, 2019 - annualreviews.org
Epstein–Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide,
and viral genes are expressed in the malignant cells. EBV also very efficiently causes the …

Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors

A Kacen, A Javitt, MP Kramer, D Morgenstern… - Nature …, 2023 - nature.com
Post-translational modification (PTM) of antigens provides an additional source of
specificities targeted by immune responses to tumors or pathogens, but identifying antigen …

Epstein–Barr virus: more than 50 years old and still providing surprises

LS Young, LF Yap, PG Murray - Nature reviews cancer, 2016 - nature.com
It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was
discovered. EBV has subsequently been found to be associated with a diverse range of …

Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment

C Steidl, JM Connors, RD Gascoyne - Journal of Clinical Oncology, 2011 - ascopubs.org
Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …

Familial predisposition and genetic risk factors for lymphoma

JR Cerhan, SL Slager - Blood, The Journal of the American …, 2015 - ashpublications.org
Our understanding of familial predisposition to lymphoma (collectively defined as non-
Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia …

Epstein-Barr virus: an important vaccine target for cancer prevention

JI Cohen, AS Fauci, H Varmus, GJ Nabel - Science translational …, 2011 - science.org
Participants at the February 2011 meeting at the US National Institutes of Health on Epstein-
Barr virus (EBV) vaccine research recommend that future clinical trials have two goals …

Hodgkin lymphoma

JM Connors, W Cozen, C Steidl, A Carbone… - Nature Reviews …, 2020 - nature.com
Hodgkin lymphoma (HL) is a B cell lymphoma characterized by few malignant cells and
numerous immune effector cells in the tumour microenvironment. The incidence of HL is …

An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

PG Murray, LS Young - Blood, The Journal of the American …, 2019 - ashpublications.org
Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors
that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt …

Epstein-Barr virus and multiple sclerosis: interaction with HLA

E Sundqvist, P Sundström, M Lindén, AK Hedström… - Genes & …, 2012 - nature.com
Epstein-Barr virus (EBV) infection, history of infectious mononucleosis (IM) and HLA-A and
DRB1 have all been proposed as risk factors for multiple sclerosis (MS). Our aim was to …