Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022 - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Corneal stromal repair and regeneration

RR Mohan, D Kempuraj, S D'Souza, A Ghosh - Progress in retinal and eye …, 2022 - Elsevier
The cornea is a specialized, transparent, avascular, immune-privileged, and heavily
innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and …

Systemic diseases and the cornea

R Shah, C Amador, K Tormanen, S Ghiam… - Experimental eye …, 2021 - Elsevier
There is a number of systemic diseases affecting the cornea. These include endocrine
disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections …

Diabetic keratopathy: Insights and challenges

S Priyadarsini, A Whelchel, S Nicholas, R Sharif… - Survey of …, 2020 - Elsevier
Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most
frequent clinical condition affecting the human cornea, is a potentially sight-threatening …

Effects of vernonia amygdalina fractionate on glutathione reductase and glutathione-S-transferase on alloxan induced diabetes wistar rat

PN Onyibe, GI Edo, LC Nwosu, E Ozgor - Biocatalysis and Agricultural …, 2021 - Elsevier
Abstracts This research was conducted to examine the effect of vernonia amygdalina on
Glutathione reductase and Glutathione-S-transferase in alloxan induced diabetic wistar rats …

Thermo-gelling dendronized chitosans as biomimetic scaffolds for corneal tissue engineering

L Feng, R Liu, X Zhang, J Li, L Zhu, Z Li… - … applied materials & …, 2021 - ACS Publications
Biomimetic scaffolds with transparent, biocompatible, and in situ-forming properties are
highly desirable for corneal tissue engineering, which can deeply fill corneal stromal defects …

Biomechanics of keratoconus: Two numerical studies

N Falgayrettes, E Patoor, F Cleymand, Y Zevering… - PloS one, 2023 - journals.plos.org
Background The steep cornea in keratoconus can greatly impair eyesight. The etiology of
keratoconus remains unclear but early injury that weakens the corneal stromal architecture …

Nutritional and metabolic imbalance in keratoconus

RM Lasagni Vitar, F Bonelli, P Rama, G Ferrari - Nutrients, 2022 - mdpi.com
Keratoconus (KC) is a progressive corneal degeneration characterized by structural
changes consisting of progressive thinning and steepening of the cornea. These alterations …

Collagen-derived peptides in CKD: a link to fibrosis

E Mavrogeorgis, H Mischak, A Latosinska, A Vlahou… - Toxins, 2021 - mdpi.com
Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …

Risk factors for fluctuations in corneal endothelial cell density

R Vaiciuliene, N Rylskyte… - Experimental and …, 2022 - spandidos-publications.com
The cornea is a transparent, avascular and abundantly innervated tissue through which light
rays are transmitted to the retina. The innermost layer of the cornea, also known as the …